Fusion gene

Fusion gene is a hybrid gene that results from the combination of two previously separate genes. It can occur as a result of translocation, interstitial deletion, or chromosomal inversion. Fusion genes are often found in cancer cells, where they can function as oncogenes.

Formation of Fusion Genes[edit | edit source]

Fusion genes are formed through various genetic alterations such as translocation, interstitial deletion, or chromosomal inversion. These alterations can lead to the combination of two previously separate genes, resulting in a hybrid or fusion gene.

Role in Cancer[edit | edit source]

Fusion genes play a significant role in the development of many types of cancer. They can function as oncogenes, driving the growth and proliferation of cancer cells. Some well-known fusion genes include BCR-ABL1 in chronic myeloid leukemia, EML4-ALK in non-small cell lung cancer, and TMPRSS2-ERG in prostate cancer.

Detection of Fusion Genes[edit | edit source]

The detection of fusion genes can be achieved through various methods such as fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR), and next-generation sequencing. These methods can help in the diagnosis and treatment of cancers associated with fusion genes.

Treatment Targeting Fusion Genes[edit | edit source]

Fusion genes can be targeted for cancer treatment. For example, the drug imatinib targets the BCR-ABL1 fusion gene in chronic myeloid leukemia, and crizotinib targets the EML4-ALK fusion gene in non-small cell lung cancer.

See Also[edit | edit source]

Fusion gene Resources
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