GM-CSF

GM-CSF (Granulocyte-macrophage colony-stimulating factor) is a protein produced by the body that stimulates the growth of certain white blood cells. GM-CSF is used to increase white blood cells following chemotherapy.

Overview

GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes can go on to become macrophages. GM-CSF is secreted by a number of different cell types including T cells, macrophages, mast cells, natural killer cells, endothelial cells and fibroblasts.

Medical Uses

In medicine, it is used as a medication to stimulate the production of white blood cells to decrease the risk of infection in those with low white blood cells due to chemotherapy. It has been used in those with severe congenital neutropenia and leukemia.

Side Effects

Common side effects include fever, muscle pain, bone pain, and tiredness. Serious side effects may include an increased risk of other cancers, abnormal heart rhythms, and lung disease.

See Also

• Cytokine
• Chemotherapy
• White blood cell
• Granulocyte
• Monocyte
• Macrophage

References

GM-CSF Resources
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