Glycolytic

Glycolytic refers to the metabolic pathway that converts glucose C₆H₁₂O₆, into pyruvate, CH₃COCOO⁻ & H⁺. The free energy released in this process is used to form the high-energy molecules ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide).

Process

The glycolytic pathway can be divided into two phases:

1. The Preparatory Phase – This phase consumes energy to convert the glucose into fructose 1,6-bisphosphate.
2. The Pay Off Phase – This phase produces ATP and NADH.

Regulation

Glycolysis is regulated by three key enzymes: hexokinase, phosphofructokinase, and pyruvate kinase.

Clinical significance

Defects in glycolysis have been linked to different diseases including Pyruvate kinase deficiency, Glycogen storage disease type VII and Hemolytic anemia.

See also

• Gluconeogenesis
• Citric acid cycle
• Pentose phosphate pathway

References

Glycolytic Resources
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