Hemophilia a

Hemophilia A is a genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding longer after an injury, easy bruising, and an increased risk of bleeding inside joints or the brain.

Causes

Hemophilia A is caused by a mutation in the Factor VIII gene, which is located on the X chromosome. This gene provides instructions for making a protein that is essential for blood clotting.

Symptoms

The symptoms of Hemophilia A can range from mild to severe, depending on the amount of Factor VIII in the blood. Common symptoms include:

• Bleeding into joints and muscles
• Spontaneous or sudden bleeding episodes
• Prolonged bleeding after injuries or surgery
• Unexplained and easy bruising
• Blood in urine or stool

Diagnosis

Diagnosis of Hemophilia A typically involves blood tests to measure the level of clotting factors in the blood. A low level of Factor VIII is indicative of Hemophilia A.

Treatment

Treatment for Hemophilia A usually involves replacing the missing Factor VIII in the blood through infusions. Other treatments may include medications to stimulate the release of Factor VIII and physical therapy to help manage symptoms.

See Also

• Hemophilia
• Factor VIII
• Blood clot
• X chromosome

Hemophilia a Resources
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