IL-1B

IL-1B is a protein that in humans is encoded by the IL1B gene. It is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

Function

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

Clinical significance

The synthesis of IL-1B is induced by various inflammatory stimuli and is produced by a variety of cells. It is involved in several disease states including inflammatory bowel disease, rheumatoid arthritis, Alzheimer's disease, and cancer.

See also

• Interleukin 1
• Cytokine
• Macrophage
• Caspase 1
• Inflammatory bowel disease
• Rheumatoid arthritis
• Alzheimer's disease
• Cancer

External links

• IL-1B at WikiMD

IL-1B Resources
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