IgD

IgD is a type of antibody that is found in small amounts in the blood. It is one of the five classes of immunoglobulins, which are proteins that play a key role in the immune system by binding to specific foreign substances, such as bacteria and viruses, and helping to destroy them.

Structure

IgD, or Immunoglobulin D, is a monomeric antibody. It is composed of two heavy chains (δ chains) and two light chains, with each heavy chain consisting of one variable domain (VH) and three constant domains (CH1, CH2, and CH3).

Function

The exact function of IgD is not well understood. However, it is known to be present on the surface of B cells, where it can bind to antigens and trigger a B cell response. This suggests that IgD may play a role in the activation and differentiation of B cells.

Clinical significance

Abnormal levels of IgD can be indicative of certain health conditions. For example, elevated levels of IgD can be seen in patients with IgD multiple myeloma, a rare form of multiple myeloma. Additionally, high levels of IgD can also be seen in individuals with hyper-IgD syndrome, a rare genetic disorder characterized by periodic fevers and inflammation.

See also

• Immunoglobulin
• B cell
• Antibody
• Immune system
• IgD multiple myeloma
• Hyper-IgD syndrome

IgD Resources
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