Inflammasome
Inflammasome is a multiprotein oligomer responsible for the activation of inflammatory responses. The inflammasome promotes the maturation and secretion of pro-inflammatory cytokines IL-1β and IL-18.
Structure[edit | edit source]
The inflammasome complex is composed of a sensor molecule, an adaptor protein ASC, and an effector protein caspase-1. The sensor molecule, which can be a member of the NLR or ALR family, detects pathogenic microorganisms and sterile stressors.
Function[edit | edit source]
Inflammasomes respond to a wide range of stimuli, including microbial pathogens, molecules derived from host proteins, and foreign substances. Upon activation, the inflammasome forms a platform for the activation of caspase-1, which subsequently cleaves the pro-inflammatory cytokines IL-1β and IL-18 into their active forms.
Role in Disease[edit | edit source]
Inflammasomes play a crucial role in the innate immune response, and their dysregulation can lead to a variety of diseases, including autoinflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD