Interleukin-1-alpha

Interleukin-1 alpha (IL-1α) is a protein that in humans is encoded by the IL1A gene. It is a part of the interleukin-1 family, a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.

Function

IL-1α is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

Clinical Significance

The aberrant production of IL-1α is associated with a variety of inflammatory diseases including rheumatoid arthritis, skin diseases, and cancer.

See Also

• Interleukin-1
• Interleukin-1 beta
• Interleukin-1 family
• Cytokines
• Macrophages
• Caspase 1
• Rheumatoid arthritis
• Skin diseases
• Cancer

External Links

• Interleukin-1 alpha at UniProt

Interleukin-1-alpha Resources
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