Keyhole limpet hemocyanin

Keyhole Limpet Hemocyanin (KLH) is a large, multisubunit, oxygen-carrying, metalloprotein that is found in the hemolymph of the giant keyhole limpet species, Megathura crenulata. KLH is renowned for its immunogenic properties and is commonly used in biomedical research.

Structure

KLH is composed of two distinct subunits, KLH1 and KLH2, which are assembled into didecamers and multidecamers, respectively. The protein is a copper-containing oxygen carrier, similar to hemoglobin in vertebrates, but with a significantly more complex structure.

Uses

KLH is widely used in research and clinical applications due to its strong immunogenic response. It is often used as a carrier protein in the production of antibodies, as well as in immunotoxicology studies. KLH has also been used in the development of vaccines, including cancer vaccines.

Safety and Side Effects

KLH is generally considered safe for use in humans, with few reported side effects. However, as with any substance, individual reactions can vary and potential side effects should always be considered.

See Also

• Megathura crenulata
• Immunogenicity
• Vaccine
• Antibody

Keyhole limpet hemocyanin Resources
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