Large-cell acanthoma

Large-cell acanthoma is a benign skin lesion that is characterized by its large, pale-staining keratinocytes. It is a rare condition that is often mistaken for other skin conditions, such as actinic keratosis or squamous cell carcinoma.

History[edit | edit source]

Large-cell acanthoma was first described in 1968 by the dermatologist Robert Degos. It was initially thought to be a variant of seborrheic keratosis, but further studies have shown that it is a distinct entity.

Characteristics[edit | edit source]

Large-cell acanthoma typically presents as a solitary, well-demarcated, flat or slightly raised lesion. It is usually found on sun-exposed areas of the body, such as the face, neck, and arms. The lesion is often asymptomatic, but it may cause mild itching or discomfort.

Histologically, large-cell acanthoma is characterized by an increased number of large, pale-staining keratinocytes in the epidermis. These cells are larger than the surrounding keratinocytes and have a clear or pale cytoplasm. The dermis underneath the lesion may show signs of solar elastosis, indicating chronic sun damage.

Diagnosis[edit | edit source]

The diagnosis of large-cell acanthoma is usually made based on the clinical appearance of the lesion and the histological findings. A skin biopsy may be performed to confirm the diagnosis and to rule out other skin conditions.

Treatment[edit | edit source]

Treatment for large-cell acanthoma is usually not necessary, as the condition is benign and does not pose a risk for malignancy. However, if the lesion is bothersome or cosmetically unacceptable, it can be removed by surgical excision or cryotherapy.