MGUS

Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein, known as monoclonal protein or M protein, is found in the blood. MGUS is considered a precancerous condition and is associated with a small risk of progressing to multiple myeloma or related diseases.

Signs and Symptoms

Most people with MGUS have no symptoms, and the condition is often discovered during blood tests performed for another reason. In some cases, MGUS can cause problems related to the high levels of M protein in the blood, such as nerve damage, blood clots, and kidney problems.

Causes

The exact cause of MGUS is unknown. It is more common in older adults and in people of African descent. There is also a higher incidence of MGUS in people with a family history of the condition.

Diagnosis

MGUS is diagnosed through blood tests that measure the levels of different types of proteins in the blood. If high levels of M protein are found, further tests may be performed to rule out multiple myeloma and other related diseases.

Treatment

There is no cure for MGUS, but the condition is monitored closely for signs of progression to more serious diseases. Treatment is not usually necessary unless the patient develops symptoms or the condition progresses.

See Also

• Multiple Myeloma
• Plasma Cell Dyscrasias
• Monoclonal Gammopathy

References

MGUS Resources
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