MUC-1

MUC1 (also known as Mucin 1 or CD227) is a mucin type glycoprotein expressed on the apical surface of most epithelial cells. It is encoded by the MUC1 gene in humans. MUC1 plays a key role in cell signaling, and has been implicated in cancer progression and metastasis.

Structure[edit | edit source]

MUC1 is a large, transmembrane protein that consists of a variable number of tandem repeats (VNTR) region, a transmembrane domain, and a cytoplasmic tail. The VNTR region is heavily glycosylated and projects from the cell surface, where it can interact with the extracellular environment.

Function[edit | edit source]

MUC1 is involved in a variety of cellular functions, including cell-cell adhesion, signal transduction, and immune response. It acts as a physical barrier, protecting the cell surface from proteolytic enzymes and physical damage. In addition, MUC1 can interact with various signaling molecules and modulate their activity, influencing cell proliferation, survival, and differentiation.

Role in disease[edit | edit source]

Alterations in MUC1 expression and glycosylation are often observed in cancer. Overexpression of MUC1 is associated with many types of cancer, including breast, ovarian, lung, and pancreatic cancer. In these cases, MUC1 may contribute to tumor progression by promoting cell proliferation, inhibiting apoptosis, and enhancing cell motility and invasiveness. Furthermore, the abnormal glycosylation of MUC1 in cancer cells can lead to the generation of tumor-associated antigens, which can be recognized by the immune system and may serve as targets for cancer immunotherapy.

See also[edit | edit source]

MUC-1 Resources
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