Malondialdehyde

Malondialdehyde (MDA) is an organic compound with the formula CH2(CHO)2. It is a colorless liquid and is a product of lipid peroxidation and is a marker for oxidative stress.

Structure and synthesis

MDA is a three-carbon dialdehyde. It is produced by the decomposition of polyunsaturated lipids in the body. It is a reactive aldehyde and is one of the many reactive electrophile species that cause toxic stress in cells and form covalent protein adducts referred to as advanced lipoxidation end-products (ALE), in analogy to advanced glycation end-products (AGE).

Biological implications

MDA is reactive and potentially mutagenic. It has been found to cause DNA adducts, which can lead to DNA damage and potentially cause mutations that can lead to cancer. It is also involved in aging and neurological diseases.

Measurement

MDA is often measured as a biomarker for oxidative stress. The thiobarbituric acid reactive substances (TBARS) assay is the most commonly used method for the detection of MDA.

See also

• Lipid peroxidation
• Oxidative stress
• DNA adduct
• Advanced lipoxidation end-products

References

Malondialdehyde Resources
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