Neutrophilic eccrine hidradenitis

Neutrophilic eccrine hidradenitis (NEH) is a rare skin disease that primarily affects the eccrine glands, which are a type of sweat gland. It is characterized by the presence of neutrophils in the eccrine glands, hence the name. The condition was first described in 1982 and is often associated with chemotherapy in patients with leukemia, although it can also occur in healthy individuals.

Symptoms and signs

The most common symptoms of NEH include painful, red or purple skin lesions that typically occur on the head, neck, and upper body. These lesions may be accompanied by fever, fatigue, and general discomfort. In some cases, the affected skin may also develop ulcers.

Causes

While the exact cause of NEH is unknown, it is often associated with chemotherapy treatment in patients with leukemia. Other potential triggers include infection, stress, and certain medications. It is thought that these factors may cause an abnormal response in the eccrine glands, leading to inflammation and the characteristic skin lesions.

Diagnosis

Diagnosis of NEH is typically based on the characteristic skin lesions and a history of potential triggers such as chemotherapy. A biopsy of the affected skin is often performed to confirm the diagnosis. This typically shows neutrophils in the eccrine glands, which is the hallmark of the condition.

Treatment

Treatment of NEH primarily involves managing the symptoms and addressing the underlying cause, if known. This may include discontinuing any triggering medications, treating any underlying infections, and providing supportive care for symptoms such as pain and fever. In some cases, corticosteroids may be used to reduce inflammation.

Prognosis

The prognosis for NEH is generally good, with most patients experiencing a complete resolution of symptoms within a few weeks. However, in some cases, the condition may recur, particularly if the underlying cause is not addressed.

See also

• Eccrine gland
• Neutrophil
• Chemotherapy
• Leukemia

Neutrophilic eccrine hidradenitis Resources
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