Nortilidine

Nortilidine is an active metabolite of the synthetic opioid analgesic drug Tramadol. It is produced in the liver after the consumption of Tramadol and is believed to be responsible for most of Tramadol's analgesic effects.

Pharmacology[edit | edit source]

Nortilidine binds to and blocks the reuptake of neurotransmitters in the brain that are involved in pain perception, including serotonin and norepinephrine. This action is thought to contribute to its analgesic effects. Nortilidine is also a weak agonist of the mu-opioid receptor, which is the primary target of most opioid drugs.

Metabolism[edit | edit source]

Nortilidine is produced in the liver by the enzyme CYP2D6, which metabolizes Tramadol into Nortilidine. The amount of Nortilidine produced can vary greatly between individuals, depending on their genetic makeup and the activity of their CYP2D6 enzyme. This variability can affect the analgesic efficacy and side effects of Tramadol.

Side Effects[edit | edit source]

The side effects of Nortilidine are similar to those of other opioids and can include nausea, vomiting, constipation, dizziness, and sedation. In rare cases, serious side effects such as respiratory depression and seizures can occur.

See Also[edit | edit source]

Nortilidine Resources
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