Nrf2

Nrf2 (Nuclear factor erythroid 2-related factor 2) is a transcription factor that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Function

Nrf2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Nrf2 is bound to the protein Keap1, which helps to degrade Nrf2. After oxidative stress, Nrf2 is released from Keap1 and then translocates into the nucleus, where it binds to the antioxidant response element (ARE) located in the promoter of genes coding for antioxidant/detoxifying enzymes and scavengers.

Clinical significance

Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress. Nrf2 is a key protein in the regulation of oxidative stress, which is thought to be involved in the pathogenesis of many diseases, including neurodegenerative diseases, cardiovascular diseases, and cancer.

See also

• Oxidative stress
• Antioxidant
• Keap1
• NFE2L2

References

Nrf2 Resources
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