Phenoperidine

Phenoperidine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine).

Chemistry

Phenoperidine is synthesized by the reaction of 1-benzyl-4-piperidone with two equivalents of phenylmagnesium bromide, to give the corresponding tertiary alcohol. This is then dehydrated to the double bond, and hydrogenated, to give phenoperidine.

Pharmacology

Phenoperidine has similar effects to other opioids, and produces analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening.

Legal Status

Phenoperidine is a Schedule II/Narcotic controlled substance in the United States with an ACSCN of 9641 and a 2013 annual aggregate manufacturing quota of 3 grams. The salts in use are hydrobromide (free base conversion ratio 0.741), hydrochloride (0.876), and tartrate (0.632).

See also

• Pethidine
• Fentanyl
• Alfentanil
• Sufentanil
• Remifentanil
• Carfentanil

Phenoperidine Resources
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