Promyelocytic leukemia gene
Promyelocytic leukemia gene (also known as PML) is a gene that in humans is encoded by the PML protein. This gene is involved in the formation of the PML nuclear body and it plays a critical role in apoptosis, cell proliferation, and tumor suppression.
Function[edit | edit source]
The PML gene is known to encode a protein that forms one component of a multiprotein complex known as the PML nuclear body. PML bodies are involved in a variety of important cellular processes, including apoptosis, cell proliferation, and DNA damage response. The PML protein is also known to interact with a variety of other proteins, including retinoic acid receptor alpha (RARa), DAXX, and others.
Clinical significance[edit | edit source]
Mutations in the PML gene are associated with acute promyelocytic leukemia (APL). APL is a subtype of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In APL, there are too many immature blood-forming cells in the bone marrow and blood. Most cases of APL are associated with a reciprocal translocation between chromosomes 15 and 17, which fuses part of the PML gene with part of the RARa gene.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
Promyelocytic leukemia gene Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD