Rhogam
What is RhoGAM?[edit | edit source]
RhoGAM is an immune globulin.
What are the uses of this medicine?[edit | edit source]
This medication is indicated for use in preventing Rh immunization for pregnancy and other obstetrical conditions in Rh-negative women and in any Rh-negative person after incompatible transfusion of Rh-positive blood.
How does this medicine work?[edit | edit source]
- RhoGAM and MICRhoGAM act by supressing the immune response of Rh-negative individuals to Rh-positive red blood cells.
- These products are not effective in altering the course or consequences of Rh immunization once it has occurred.
Who should not use this medicine?[edit | edit source]
This medicine cannot be used for:
- Rh-positive individuals
- patients with a known history of anaphylactic or severe systemic reactions to administration of human globulin products.
Is this medicine FDA approved?[edit | edit source]
- RhoGAM was approved for use in the United States in 1968.
How should this medicine be administered?[edit | edit source]
- RhoGAM and MICRhoGAM should be for intramuscular use only.
- RhoGAM should be administered within 72 hours of delivery postpartum if the newborn is Rh-positive. It can also be administered antepartum within 72 hours of suspected or proven exposure to Rh-positive red blood cells.
- MICRhoGAM should be administered within 72 hours if there is an actual or threatened termination of pregnancy up to and including 12 weeks gestation.
- RhoGAM may be administered if MICRhoGAM is not available.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in the following dosage forms:
- MICRhoGAM Ultra-Filtered PLUS - 50 μg (250 IU) Dose
- RhoGAM Ultra-Filtered PLUS - 300 μg (1500 IU) Dose
What side effects can this medication cause?[edit | edit source]
Common possible side effects of this medicine include local reactions such as:
- swelling
- slight elevation in temperature
- induration
- redness and mild pain at the site of injection
What special precautions should I follow?[edit | edit source]
- Severe hypersensitivity reactions may occur with the use of RhoGAM and MICRhoGAM.
- RhoGAM and MICRhoGAM should be administered in a setting where appropriate equipment, medications such as epinephrine, and personnel trained in the management of hypersensitivity, anaphylaxis, and shock are available.
- Patients treated for Rh-incompatible transfusion should be monitored by clinical and laboratory means for signs and symptoms of a hemolytic reaction.
What to do in case of emergency/overdose?[edit | edit source]
- There are no reports of known overdoses in patients treated with RhoGAM.
Can this medicine be used in pregnancy?[edit | edit source]
- RhoGAM is used in pregnant women for the supression of Rh isoimmunization. This medication does not harm the fetus or affect reproduction capacity.
Can this medicine be used in children?[edit | edit source]
- The safety and effectiveness of RhoGAM in pediatric patients have not been established.
What should I know about storage of this medication? [edit | edit source]
- Store at 2 to 8°C. Do not store frozen.
- Do not use after the expiration date printed on the syringe.
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