Ribostamycin
Ribostamycin is an aminoglycoside antibiotic that is derived from Streptomyces ribosidificus. It is used in the treatment of various bacterial infections, particularly those caused by Gram-negative bacteria. Ribostamycin works by binding to the bacterial ribosome, inhibiting protein synthesis and thereby killing the bacteria.
History[edit | edit source]
Ribostamycin was first isolated in 1968 from Streptomyces ribosidificus, a species of actinobacteria that is found in soil. The discovery of ribostamycin was part of a larger effort to find new antibiotics that could be used to treat drug-resistant bacterial infections.
Medical uses[edit | edit source]
Ribostamycin is used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, and skin infections. It is particularly effective against Gram-negative bacteria, such as Escherichia coli and Klebsiella pneumoniae.
Mechanism of action[edit | edit source]
Ribostamycin works by binding to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis. This prevents the bacteria from growing and reproducing, effectively killing them.
Side effects[edit | edit source]
Like other aminoglycoside antibiotics, ribostamycin can cause ototoxicity and nephrotoxicity. Other potential side effects include allergic reactions and gastrointestinal distress.
See also[edit | edit source]
Ribostamycin Resources | ||
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