SIRS
SIRS or Systemic Inflammatory Response Syndrome is a condition that can occur in response to various severe clinical insults. It is characterized by changes in temperature, heart rate, respiratory rate, and white blood cell count.
Definition[edit | edit source]
The definition of SIRS was established in 1991 by the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM). According to these criteria, a patient is diagnosed with SIRS if they meet two or more of the following conditions:
- Temperature >38°C or <36°C
- Heart rate >90 beats per minute
- Respiratory rate >20 breaths per minute or PaCO2 <32 mm Hg
- White blood cell count >12,000/cu mm, <4,000/cu mm, or >10% immature (band) forms
Causes[edit | edit source]
SIRS can be caused by a variety of conditions, including infection, trauma, surgery, pancreatitis, and others. It is important to note that SIRS can occur without infection, in which case it is not considered sepsis.
Treatment[edit | edit source]
The treatment of SIRS is primarily supportive and depends on the underlying cause. This may include antibiotics for infection, fluid resuscitation for hypovolemia, and vasopressors for hypotension.
Prognosis[edit | edit source]
The prognosis of SIRS depends on the underlying cause and the patient's overall health status. In general, the mortality rate of SIRS is high, especially in patients with multiple organ dysfunction syndrome (MODS).
See also[edit | edit source]
SIRS Resources | ||
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Contributors: Prab R. Tumpati, MD