Senolytic

Senolytic is a type of drug that selectively induces apoptosis of senescent cells. Senescent cells are cells that have stopped dividing and have accumulated in the body with age. They contribute to aging and age-related diseases. Senolytics are a potential therapy for these diseases.

Mechanism of Action

Senolytics work by selectively inducing apoptosis, or programmed cell death, in senescent cells. They do this by inhibiting the survival pathways that these cells rely on. The two main pathways targeted by senolytics are the BCL-2 pathway and the PI3K/AKT pathway.

Types of Senolytics

There are several types of senolytics, including:

• Quercetin: A plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, and grains.
• Dasatinib: A medication used to treat certain cases of chronic myelogenous leukemia and acute lymphoblastic leukemia.
• Navitoclax: A drug that has been used in trials studying the treatment of lymphoma, leukemia, and solid tumors.

Potential Applications

Senolytics have potential applications in a variety of age-related diseases, including:

• Cardiovascular disease: Senescent cells contribute to the development and progression of cardiovascular disease. Senolytics could potentially be used to reduce the burden of these cells and slow the progression of the disease.
• Osteoarthritis: Senescent cells accumulate in the joints with age and contribute to the development of osteoarthritis. Senolytics could potentially be used to reduce the burden of these cells and slow the progression of the disease.
• Alzheimer's disease: Senescent cells contribute to the development and progression of Alzheimer's disease. Senolytics could potentially be used to reduce the burden of these cells and slow the progression of the disease.

Research

Research into senolytics is ongoing, with several clinical trials currently underway. These trials aim to determine the safety and efficacy of senolytics in humans.

See Also

• Senescence
• Apoptosis
• Age-related disease

References

Senolytic Resources
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