Sincalide

Sincalide is a choleretic and cholecystokinetic agent that is used in diagnostic procedures to assess gallbladder function and to diagnose gastrointestinal disorders. It is a synthetic octapeptide that is identical to the C-terminal octapeptide of cholecystokinin (CCK), a hormone that stimulates the gallbladder to contract and release bile.

Pharmacology

Sincalide binds to the cholecystokinin B receptor (CCKBR), which is found primarily in the gastrointestinal tract and the brain. Activation of this receptor leads to increased intracellular calcium levels, which in turn stimulate gallbladder contraction and the release of pancreatic enzymes.

Clinical use

Sincalide is used in a test called the sincalide-stimulated cholescintigraphy test, which is used to diagnose problems with gallbladder function. It is also used in the sincalide-stimulated secretin test, which is used to diagnose problems with pancreatic function.

Side effects

Common side effects of sincalide include nausea, abdominal pain, and diarrhea. Rare side effects include hypotension, flushing, and urticaria.

See also

• Cholecystokinin
• Cholecystokinin B receptor
• Cholescintigraphy

Sincalide Resources
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