TP53 gene

TP53 (also known as p53) is a gene that in humans is encoded by the TP53 gene. It is crucial for preventing cancer. In its role as a tumor suppressor, TP53 works primarily through its transcriptional activity, controlling the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer.

Function

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too rapidly or in an uncontrolled way.

Clinical significance

Mutations in the TP53 gene are associated with a variety of human cancers, including lung cancer, ovarian cancer, colorectal cancer, pancreatic cancer, stomach cancer, leukemia, and lymphoma. TP53 mutations can be inherited or acquired, and most are acquired. Inherited mutations are present in every cell, while acquired mutations occur in individual cells during the person's life.

See also

• Tumor suppressor gene
• Oncogene
• Cancer

References

TP53 gene Resources
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