Transient abnormal myelopoiesis

Transient Abnormal Myelopoiesis (TAM) is a condition that affects newborns, particularly those with Down Syndrome. It is characterized by an abnormal increase in the number of myeloid cells, a type of white blood cell, in the blood.

Symptoms and Diagnosis

The symptoms of TAM can vary greatly, but often include hepatomegaly (enlarged liver), thrombocytopenia (low platelet count), and leukocytosis (high white blood cell count). Diagnosis is typically made through a blood test, which will show an increased number of myeloid cells.

Causes and Risk Factors

The exact cause of TAM is unknown, but it is believed to be related to the presence of the GATA1 mutation. This mutation is found in nearly all cases of TAM. Risk factors for developing TAM include being born with Down Syndrome and having a sibling who has had TAM.

Treatment and Prognosis

Treatment for TAM typically involves supportive care, such as blood transfusions to manage symptoms. In some cases, chemotherapy may be used. The prognosis for TAM is generally good, with most children recovering within a few months. However, some children may go on to develop acute myeloid leukemia (AML).

See Also

• Down Syndrome
• Acute Myeloid Leukemia
• GATA1

References

Transient abnormal myelopoiesis Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski