Virazole

Virazole (also known as Ribavirin) is an antiviral drug used in the treatment of various viral infections. It is a synthetic, nucleoside analogue with broad-spectrum antiviral activity.

History

Virazole was first synthesized in the 1970s and has since been used in the treatment of a variety of viral infections. It was initially developed by the pharmaceutical company ICN Pharmaceuticals.

Mechanism of Action

Virazole works by inhibiting the synthesis of viral RNA. It is converted into its monophosphate form by the enzyme adenosine kinase, which is then converted into the active triphosphate form by other cellular enzymes. This active form inhibits the viral RNA-dependent RNA polymerase, thus preventing viral replication.

Uses

Virazole is used in the treatment of a number of viral infections, including Hepatitis C, Respiratory Syncytial Virus (RSV) infection, and some viral hemorrhagic fevers. It is often used in combination with other antiviral drugs to increase efficacy.

Side Effects

Common side effects of Virazole include fatigue, headache, nausea, and insomnia. More serious side effects can include anemia, birth defects if taken during pregnancy, and severe depression.

See Also

• Antiviral drug
• Hepatitis C
• Respiratory Syncytial Virus (RSV)

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