Wegener

Wegener's granulomatosis (also known as Granulomatosis with polyangiitis or GPA) is a rare type of autoimmune disease that causes inflammation of the blood vessels, or vasculitis. This inflammation can restrict blood flow to various organs, often severely affecting the kidneys and lungs. The disease is named after the German pathologist Friedrich Wegener, who first described the condition in 1936.

Symptoms

The symptoms of Wegener's granulomatosis can vary greatly from person to person, and depend on what parts of the body are affected. Common symptoms include fatigue, weight loss, fever, night sweats, shortness of breath and bloody sputum. Other symptoms can include joint pain, sinusitis, skin sores and eye problems.

Causes

The exact cause of Wegener's granulomatosis is unknown, but it is believed to be an autoimmune disorder. This means that the body's immune system mistakenly attacks its own tissues, causing inflammation and damage. Some researchers believe that a viral or bacterial infection may trigger the disease in people who are genetically predisposed to it.

Diagnosis

Diagnosis of Wegener's granulomatosis can be challenging, as its symptoms can mimic those of other conditions. Doctors typically use a combination of physical examination, medical history, blood tests, chest X-rays, and biopsy of affected tissue to make a diagnosis.

Treatment

Treatment for Wegener's granulomatosis typically involves medications to reduce inflammation and suppress the immune system. These can include corticosteroids and immunosuppressive drugs. In severe cases, a type of chemotherapy may be used. Early diagnosis and treatment can significantly improve the prognosis for people with this disease.

See also

• Vasculitis
• Autoimmune disease
• Friedrich Wegener

References

Wegener Resources
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