Yohimbin

Yohimbine is an indole alkaloid derived from the bark of the African tree Pausinystalia johimbe; also from the bark of the unrelated South American tree Aspidosperma quebracho-blanco. Yohimbine is an alpha-2 adrenergic antagonist, and has been used in a variety of research projects. It is a veterinary drug used to reverse sedation in dogs and deer.

Chemistry[edit | edit source]

Yohimbine is a member of the alkaloid family of compounds. It is classified as an indole alkaloid, which means it contains a core structure of an indole ring. This ring is a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.

Pharmacology[edit | edit source]

Yohimbine has high affinity for the alpha-2 adrenergic receptor, and is commonly used in scientific research to induce a 'fight or flight' response in animals. It also has a moderate affinity for the serotonin 1A receptor, and a low affinity for the dopamine D2 receptor.

Medical uses[edit | edit source]

Yohimbine has been used in the treatment of erectile dysfunction. It is thought to work by increasing blood flow to the penis, although the exact mechanism of action is not fully understood. It has also been used to treat hypotension (low blood pressure), as it can increase blood pressure.

Side effects[edit | edit source]

Common side effects of yohimbine include increased heart rate, high blood pressure, and anxiety. Less common side effects include dizziness, headache, and skin flushing.

See also[edit | edit source]

Yohimbin Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.