File:1-s2.0-S0022283615006762-gr1-C.jpg

No higher resolution available.

1-s2.0-S0022283615006762-gr1-C.jpg (512 × 410 pixels, file size: 163 KB, MIME type: image/jpeg)

Summary[edit]

Summary
Description	Schematic of the bacteriophage MS2 lifecycle. Virions initially bind to the sides of the bacterial pilus via the MP. MPs are an essential single-copy structural component of RNA phages. By a mechanism that remains largely obscure, the RNA–MP complex but not the remaining capsid shell enters the cell. MP also binds to its own PSs located toward either end of the MS2 genome. Recent asymmetric reconstruction of the MS2–pilus complex suggests that MP replaces a CP dimer of the C/C conformer in an otherwise entirely icosahedral protein shell, from which position it is ideally placed to contact the cellular receptor and escort the RNA into the cytoplasm. Note that the presence of the asymmetric MP component could not be detected in averaged X-ray and EM density maps. Once internalized, the MP is cleaved into two separate fragments by protease, allowing translation and replication to start. Temporal control of phage gene expression then regulates the production of progeny genomes and structural proteins that assemble prior to the action of the phage lysis protein.
Source	Wikimedia Commons file page
Author	Óttar Rolfsson, Stefani Middleton, Iain W. Manfield, Simon J. White, Baochang Fan, Robert Vaughan, Neil A. Ranson, Eric Dykeman, Reidun Twarock, James Ford, C. Cheng Kao, Peter G. Stockley
Permission	See original Commons license details.

Creative Commons Attribution 4.0 International (CC BY 4.0)

This file is licensed under the Creative Commons Attribution 4.0 International license.

You may share and adapt the material provided appropriate attribution is given.

Official license: CC BY 4.0

License page: CC BY 4.0

Original attribution and file history: Wikimedia Commons

Click on a date/time to view the file as it appeared at that time.

	Date/Time	Thumbnail	Dimensions	User	Comment
current	02:09, 7 June 2026		512 × 410 (163 KB)	Maintenance script (talk \| contribs)	== Summary == Importing file

You cannot overwrite this file.

The following file is a duplicate of this file (more details):

The following page uses this file:

This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.

If the file has been modified from its original state, some details may not fully reflect the modified file.