File:6idf psen1 notch blue asp.png
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Summary[edit]
| Summary | |
|---|---|
| Description | The structure of the human presenilin-1 protein (orange) interacting with a fragment of one of its protein substrates, Notch (green). The catalytic aspartate sites are highlighted in blue spheres. Rendered using PyMOL from chains B and E of PDB: 6IDF, a cryo-electron microscopy structure of the assembled gamma-secretase protein complex. In the construct used for the structure, D385 (aspartate on the left) was mutated to alanine; this residue has been modeled as an aspartate in this image for illustrative purposes.
Structural basis of Notch recognition by human gamma-secretase Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., Lei, J., Shi, Y. (2019) Nature 565: 192-197. PubMed: 30598546 DOI: 10.1038/s41586-018-0813-8 |
| Source | Wikimedia Commons file page |
| Author | Opabinia regalis |
| Permission | See original Commons license details. |
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License page: CC BY-SA 4.0
Original attribution and file history: Wikimedia Commons
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| current | 02:07, 7 June 2026 | | 800 × 800 (368 KB) | Maintenance script (talk | contribs) | == Summary == Importing file |
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