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Summary[edit]

Summary
Description Mechanisms of VSG switching in T. brucei: A. Structure of the expression site including the expression site associated genes (ESAG), 70 base pair repeat up-stream sequence, expressed VSG gene, and the telomere B. Mechanism of array VSG conversion: A silent VSG is copied from a subtelomeric VSG array into an ES, where it replaces the active VSG. C. Telomeric VSG conversion: A telomeric VSG (including 70 bp repeat sequence upstream and telomere downstream) replaces the active VSG in the ES D. Segmental VSG conversion: Sequence is copied from multiple inactive VSG genes and combined into a novel mosaic VSG that occupies the ES E. Transcriptional VSG switching: A non-recombination based mechanism that activates a new (previously silent) ES, while inactivating the previously active ES.
Source Wikimedia Commons file page
Author Chris Stockdale, Michal R. Swiderski, J. David Barry, Richard McCulloch
Permission See original Commons license details.

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Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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current03:25, 5 June 2026Thumbnail for version as of 03:25, 5 June 20261,498 × 738 (504 KB)Maintenance script (talk | contribs)== Summary == Importing file

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