File:Melanosis coli intermed mag.jpg

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Summary[edit]

Summary
Description Intermediate magnification micrograph of melanosis coli (MC), also pseudomelanosis coli (PMC). Colonic biopsy. HPS stain.

Melanosis coli is a misnomer, as the pigmentation is due to lipofuscin-laden macrophages - not melanin pigment. Pseudomelanosis coli is a more appropriate descriptor, but not in common usage. The differential diagnosis of brown pigmentation of the colon is:

Pseudomelanosis coli. Hemosiderin-laden macrophages (old haemorrhage). Melanin (rare). PMC is predominantly seen in the cecum and right colon (ascending colon) and associated with anthracene laxative use such as senna (Senokot).

Related images


Low mag.


Intermed. mag.


High mag.


Another case:



Intermed. mag.


High mag.


Very high mag.
Source Wikimedia Commons file page
Author Nephron
Permission See original Commons license details.

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