File:Muscle protein synthesis signaling cascades.jpg
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Summary[edit]
| Summary | |
|---|---|
| Description | Diagram of the molecular signaling cascades that are involved in myofibrillar muscle protein synthesis and mitochondrial biogenesis in response to physical exercise and specific amino acids or their derivatives (primarily leucine and beta-hydroxy beta-methylbutyrate).
Abbreviations and schematic representations: ■PLD: phospholipase D ■PA: phosphatidic acid ■mTOR: mechanistic target of rapamycin ■AMP: adenosine monophosphate ■ATP: adenosine triphosphate ■AMPK: AMP-activated protein kinase ■PGC‐1α: peroxisome proliferator-activated receptor gamma coactivator-1α ■4EBP1: eukaryotic translation initiation factor 4E-binding protein 1 ■S6K1: p70S6 kinase ■eIF4E: eukaryotic translation initiation factor 4E ■RPS6: ribosomal protein S6 ■eEF2: eukaryotic elongation factor 2 ■RE: resistance exercise; EE: endurance exercise ■Myo: myofibrillar; Mito: mitochondrial ■AA: amino acids ■↑ represents activation ■Τ represents inhibition |
| Source | Wikimedia Commons file page |
| Author | Brook MS, Wilkinson DJ, Phillips BE, Perez-Schindler J, Philp A, Smith K, Atherton PJ |
| Permission | See original Commons license details. |
Licensing[edit]
Creative Commons Attribution 4.0 International (CC BY 4.0)
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Official license: CC BY 4.0
License page: CC BY 4.0
Original attribution and file history: Wikimedia Commons
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 03:22, 5 June 2026 | | 619 × 347 (75 KB) | Maintenance script (talk | contribs) | == Summary == Importing file |
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