Corticotropin-releasing hormone receptor 2

Corticotropin-releasing hormone receptor 2 (CRHR2) is a protein that in humans is encoded by the CRHR2 gene. This receptor is a member of the G protein-coupled receptor family and is associated with the G protein Gs, which activates adenylyl cyclase to produce cyclic AMP.

Function

CRHR2 is a receptor for corticotropin-releasing hormone (CRH), a peptide hormone that plays a central role in the body's response to stress. CRH binds to CRHR2, triggering a series of reactions that ultimately result in the release of cortisol from the adrenal gland. This hormone helps the body respond to stress by increasing glucose levels in the blood and suppressing the immune system.

Clinical significance

Alterations in CRHR2 function have been associated with a variety of conditions, including anxiety disorders, depression, and irritable bowel syndrome. In addition, some studies suggest that variations in the CRHR2 gene may influence an individual's susceptibility to these and other stress-related conditions.

See also

• Corticotropin-releasing hormone receptor
• Corticotropin-releasing hormone
• G protein-coupled receptor

External links

• GeneReviews/NCBI/NIH/UW entry on CRHR2

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