9-cis retinoic acid

9-cis Retinoic Acid is a derivative of Vitamin A and is one of the naturally occurring forms of retinoic acid. It is a potent and highly selective agonist for both the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are members of the nuclear receptor superfamily of steroid hormone receptors.

Chemistry[edit | edit source]

9-cis Retinoic Acid is a molecular compound with the chemical formula C20H28O2. It is a yellow-orange crystalline solid at room temperature. The compound is highly lipophilic and is stored in the lipid components of cells and tissues.

Biology[edit | edit source]

In the body, 9-cis Retinoic Acid plays a crucial role in cell differentiation and embryonic development. It is also involved in the regulation of gene expression through its interaction with the retinoic acid receptors and the retinoid X receptors. These receptors are DNA-binding proteins that regulate gene expression by binding to specific sequences of DNA.

Medical Use[edit | edit source]

9-cis Retinoic Acid has been studied for its potential use in the treatment of various diseases, including cancer, dermatological diseases, and neurodegenerative diseases. It has been shown to inhibit the growth of certain types of cancer cells in vitro and in vivo.

Safety[edit | edit source]

Like other retinoids, 9-cis Retinoic Acid can cause birth defects if taken during pregnancy. Therefore, it is classified as a teratogen. It can also cause other side effects, such as skin irritation, dryness, and photosensitivity.