Corrin

Corin

Corrin is a heterocyclic compound that plays a significant role as the structural foundation for various compounds, including the essential vitamin B12. Known for its unique macrocyclic structure, corrin's name derives from its role as the "core" of cobalamins, which include vitamin B12.

Structure and Characteristics

The corrin macrocycle is characterized by its ring system, which sets it apart from other related compounds. Specifically:

• The corrin ring structure is comprised of four pyrrole-like subunits arranged in a cyclic manner.
• Unlike porphyrin, which is present in hemoglobin and has 20 carbons connecting its pyrrole-like units, corrin possesses 19 carbons. This makes corrin distinctly different in structural configuration.
• In corrin, the pyrrole-like rings have fully saturated "edge-carbon" centers, leading to a higher proportion of sp3 hybridized carbon atoms.
• Because of its elevated sp3 carbon count, corrin exhibits greater flexibility than porphyrin. It doesn't possess a fully conjugated character throughout its ring. Instead, its conjugation can be described as "3/4", implying that not the entire ring participates in conjugation.

Coordination Chemistry

Main article: Vitamin B12

One of the remarkable properties of corrin is its ability to bind to cobalt upon deprotonation. In the case of vitamin B12:

• The cobalt-corrin complex incorporates an additional ligand derived from benzimidazole.
• The sixth site on this cobalt-coordinated octahedral structure becomes a pivotal point, acting as a catalytic center in various biochemical reactions.
• Comparatively, the corrin ring bears resemblance to the porphyrin ring found in hemoglobin. However, the absence of one of the carbons connecting the pyrrole-like units in corrins is a distinguishing feature.

Relation to Corroles

Corroles, also termed as octadehydrocorrins, are derivatives of corrins that are fully aromatic. These compounds, while sharing similarities with corrins, have distinct properties and functions due to their full aromatic nature.

Applications and Relevance

Corrin's primary significance lies in its role in vitamin B12, an essential nutrient vital for numerous metabolic processes in the human body. Its unique structural and coordination chemistry forms the basis for many biochemical reactions, showcasing the importance of heterocyclic compounds in biology and medicine.

See also

Porphyrin Heterocyclic compound Vitamin B12 metabolism

Corrin Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski