Adenosylcobalamin

Adenosylcobalamin (also known as AdoCbl, AdoB12, Cobamamide, Dibencozide) is a coenzyme form of Vitamin B12. It is a naturally occurring form of Vitamin B12 that can be consumed through the diet, and it is synthesized by the human body from ingested cobalamin.

Overview

Adenosylcobalamin is one of the two active forms of Vitamin B12, the other being methylcobalamin. It is primarily used in the body in the mitochondria, the energy factories of cells, where it is needed for the metabolism of fatty acids and amino acids.

Function

Adenosylcobalamin plays a crucial role in the enzyme methylmalonyl-CoA mutase, which is needed for the production of energy from fats and proteins. It is also involved in the conversion of methylmalonyl-CoA to succinyl-CoA, an important step in the production of energy from proteins and fats.

Deficiency

A deficiency of adenosylcobalamin can lead to a variety of health problems, including megaloblastic anemia, neuropathy, and homocystinuria. Symptoms of deficiency can include fatigue, weakness, constipation, loss of appetite, weight loss, and neurological changes such as numbness and tingling in the hands and feet.

Sources

Dietary sources of adenosylcobalamin include animal products such as meat, eggs, and dairy products. It can also be synthesized in the body from cobalamin, which is found in these same dietary sources.

See also

• Vitamin B12
• Methylcobalamin
• Cobalamin
• Coenzyme

Adenosylcobalamin Resources
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