Etofibrate

Etofibrate.svg

Etofibrate is a fibrate class medication primarily used to treat hyperlipidemia, a condition characterized by elevated levels of lipids in the blood. It is a prodrug that is metabolized in the body to clofibric acid and nicotinic acid, both of which contribute to its lipid-lowering effects.

Mechanism of Action

Etofibrate works by activating peroxisome proliferator-activated receptors (PPARs), specifically PPAR-alpha. Activation of these receptors leads to increased expression of genes involved in lipid metabolism, resulting in decreased levels of triglycerides and low-density lipoprotein (LDL) cholesterol, and increased levels of high-density lipoprotein (HDL) cholesterol.

Indications

Etofibrate is indicated for the treatment of various forms of hyperlipidemia, including:

• Hypercholesterolemia
• Hypertriglyceridemia
• Mixed dyslipidemia

Pharmacokinetics

After oral administration, etofibrate is hydrolyzed to its active metabolites, clofibric acid and nicotinic acid. These metabolites are then absorbed into the bloodstream and exert their lipid-lowering effects. The drug is primarily excreted through the kidneys.

Side Effects

Common side effects of etofibrate include:

• Gastrointestinal disturbances
• Myopathy
• Hepatotoxicity

Contraindications

Etofibrate is contraindicated in patients with:

• Severe liver disease
• Severe kidney disease
• Known hypersensitivity to fibrates

Drug Interactions

Etofibrate may interact with other medications, including:

• Statins: Increased risk of myopathy
• Anticoagulants: Enhanced anticoagulant effect

See Also

• Fibrate
• Hyperlipidemia
• Clofibrate
• Nicotinic acid

External Links

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