Meclofenamate sodium

Meclofenamate Sodium is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat pain, including menstrual pain, and inflammatory diseases such as arthritis. It works by inhibiting the production of substances in the body that cause inflammation and pain.

Mechanism of Action[edit | edit source]

Meclofenamate sodium operates by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins. Prostaglandins are lipid compounds that play a key role in inflammation. By reducing the production of these compounds, meclofenamate sodium effectively decreases inflammation and pain.

Indications[edit | edit source]

This medication is indicated for the treatment of various conditions, including:

Rheumatoid arthritis
Osteoarthritis
Menstrual cramps or dysmenorrhea
Other conditions characterized by pain and inflammation

Dosage and Administration[edit | edit source]

The dosage of meclofenamate sodium varies depending on the condition being treated, the severity of symptoms, and the patient's response to the medication. It is important for patients to follow their healthcare provider's instructions regarding dosage. Meclofenamate sodium is typically taken orally, with food or milk to minimize gastrointestinal side effects.

Side Effects[edit | edit source]

As with all NSAIDs, meclofenamate sodium can cause side effects, although not everyone experiences them. Common side effects include:

More serious side effects may include:

Patients should seek medical attention if they experience symptoms of these more serious side effects.

Contraindications[edit | edit source]

Meclofenamate sodium is contraindicated in patients with:

Known hypersensitivity to meclofenamate sodium or other NSAIDs
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Active or history of recurrent peptic ulcer disease or gastrointestinal bleeding
Advanced renal disease

Interactions[edit | edit source]

Meclofenamate sodium can interact with other medications, which can affect how it works or increase the risk of serious side effects. It is important to inform healthcare providers of all medications being taken, including over-the-counter drugs and herbal supplements. Notable interactions include:

Anticoagulants (e.g., warfarin)
Diuretics
Lithium
Other NSAIDs

Pharmacokinetics[edit | edit source]

After oral administration, meclofenamate sodium is rapidly absorbed from the gastrointestinal tract. It undergoes metabolism in the liver and is excreted primarily in the urine.

Conclusion[edit | edit source]

Meclofenamate sodium is an effective NSAID for the treatment of pain and inflammation associated with various conditions. However, it is important for patients to be aware of the potential side effects and interactions associated with this medication. Patients should always consult their healthcare provider for advice on the use of meclofenamate sodium.