Mestranol/norethisterone

Mestranol/norethisterone is a combined oral contraceptive pill (COCP) that contains two active ingredients: mestranol and norethisterone. It is used to prevent pregnancy and is also used in the treatment of certain menstrual disorders.

Composition

Mestranol/norethisterone is composed of two synthetic hormones: mestranol, which is a synthetic form of estrogen, and norethisterone, a synthetic form of progesterone. The combination of these two hormones inhibits ovulation, thus preventing pregnancy.

Mechanism of action

Mestranol/norethisterone works by preventing the release of an egg during the menstrual cycle. It also thickens the cervical mucus, making it harder for sperm to reach the egg, and changes the lining of the uterus, making it less likely for a fertilized egg to attach and grow.

Side effects

Like all medications, mestranol/norethisterone can cause side effects. Common side effects include nausea, vomiting, headache, breast tenderness, and changes in menstrual bleeding patterns. Serious side effects are rare but can include blood clots, stroke, and heart attack.

Contraindications

Mestranol/norethisterone is contraindicated in women with a history of thromboembolic disorders, liver disease, known or suspected breast cancer, and undiagnosed vaginal bleeding.

Interactions

Mestranol/norethisterone can interact with certain medications, including antibiotics, antifungal medications, and HIV medications, which can decrease its effectiveness.

See also

• Oral contraceptive pill
• Estrogen
• Progesterone

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