Pancuronium bromide

Pancuronium bromide is a type of non-depolarizing muscle relaxant used primarily in anesthesia to achieve muscle relaxation during surgery. It is a steroidal compound and is considered a long-acting muscle relaxant.

Pharmacology

Pancuronium bromide works by blocking the nicotinic acetylcholine receptor, a type of ionotropic receptor located at the neuromuscular junction. This prevents the neurotransmitter acetylcholine from binding to these receptors, which in turn prevents muscle contraction.

Clinical Use

In the clinical setting, pancuronium bromide is used to provide muscle relaxation during general anesthesia for surgery. It is also used in intensive care units to facilitate mechanical ventilation in patients who are unable to breathe on their own.

Side Effects

The most common side effects of pancuronium bromide include hypotension, tachycardia, and skin rash. Rare but serious side effects can include anaphylaxis, a severe allergic reaction.

History

Pancuronium bromide was first synthesized in the 1960s and has since become a staple in the field of anesthesiology.

See Also

• Neuromuscular-blocking drug
• Anesthesia
• Acetylcholine

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