Trichoblastoma

Trichoblastoma is a rare, benign skin tumor that originates from the hair follicle germ cells. It is considered a type of basal cell carcinoma but with a differentiation towards hair follicle structures. Trichoblastomas are most commonly found on the head and neck region but can occur anywhere on the body. They are slow-growing tumors and are not associated with significant morbidity unless they reach a large size or are located in cosmetically sensitive areas.

Etiology

The exact cause of trichoblastoma is not well understood. However, it is believed to be related to genetic mutations that affect the normal development and differentiation of hair follicle cells. Some studies suggest a link between trichoblastomas and the PTCH1 gene, which is also implicated in the development of basal cell carcinomas.

Clinical Presentation

Trichoblastomas typically present as solitary, well-circumscribed, skin-colored or bluish nodules. They can vary in size from a few millimeters to several centimeters in diameter. The overlying skin is usually intact, but ulceration can occur in larger lesions. Patients with trichoblastoma usually report a slow-growing mass that may have been present for several years before diagnosis.

Diagnosis

The diagnosis of trichoblastoma is primarily based on histopathological examination of the tumor. Biopsy of the lesion reveals nests and strands of basaloid cells with a palisading arrangement, embedded in a fibromyxoid stroma. These features are indicative of differentiation towards hair follicle structures. Immunohistochemistry may be used to differentiate trichoblastoma from other skin tumors, with trichoblastoma cells typically expressing markers associated with hair follicle differentiation.

Treatment

The treatment of choice for trichoblastoma is surgical excision with clear margins. This approach ensures complete removal of the tumor and minimizes the risk of recurrence. Mohs micrographic surgery may be considered for lesions located in cosmetically sensitive areas to preserve as much healthy tissue as possible. There is no role for chemotherapy or radiation therapy in the treatment of trichoblastoma due to its benign nature.

Prognosis

The prognosis for trichoblastoma is excellent, with complete surgical excision being curative in most cases. Recurrence is rare but can occur, especially if the initial excision margins were inadequate. There is no evidence to suggest that trichoblastoma has malignant potential or that it can metastasize.

Epidemiology

Trichoblastoma is a rare tumor, and its exact incidence is not well documented. It can occur at any age but is most commonly diagnosed in adults. There is no clear gender predilection.

Conclusion

Trichoblastoma is a rare, benign tumor that arises from hair follicle germ cells. It presents as a slow-growing, well-circumscribed nodule, typically on the head and neck region. Diagnosis is based on histopathological examination, and treatment involves surgical excision. The prognosis is excellent, with a low risk of recurrence.

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian