Triheptanoin
What is Triheptanoin?[edit | edit source]
- Triheptanoin (DOJOLVI) is a medium-chain triglyceride indicated as a source of calories and fatty acids used to treat long-chain fatty acid oxidation disorders (LC-FAOD) in children and adults.
What are the uses of this medicine?[edit | edit source]
- This medicine is indicated for as a source of calories and fatty acids for the treatment of pediatric and adult patients with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD).
How does this medicine work?[edit | edit source]
Triheptanoin is a medium-chain triglyceride consisting of three odd-chain 7-carbon length fatty acids (heptanoate) that provide a source of calories and fatty acids to bypass the long-chain FAOD enzyme deficiencies for energy production and replacement.
Who Should Not Use this medicine ?[edit | edit source]
- This medicne have no usage limitations.
What drug interactions can this medicine cause?[edit | edit source]
- Avoid co-administration of DOJOLVI with pancreatic lipase inhibitors (e.g., orlistat).
Is this medicine FDA approved?[edit | edit source]
- It was approved for use in the United States in 2020.
How should this medicine be used?[edit | edit source]
- Assess metabolic requirements by determining daily caloric intake (DCI) prior to calculating the dosage of DOJOLVI.
- For patients receiving another medium-chain triglyceride product, discontinue prior to the first dose of DOJOLVI.
- The recommended target daily dosage of DOJOLVI is up to 35% of the patient’s total prescribed DCI divided into at least four doses and administered orally diluted with foods, liquids, or formula via a silicone or polyurethane feeding tube.
For patients not currently taking a medium-chain triglyceride product
- Initiate DOJOLVI at a total daily dosage of approximately 10% DCI divided into at least four times per day and increase to the recommended total daily dosage of up to 35% DCI over a period of 2 to 3 weeks.
For patients switching from another medium-chain triglyceride product
- Discontinue use of MCT products before starting DOJOLVI.
- Initiate DOJOLVI at the last tolerated daily dosage of MCT divided into at least four times per day. Increase the total daily dosage by approximately 5% DCI every 2 to 3 days until the target dosage of up to 35% DCI is achieved.
Administration
- Your healthcare provider may start you on a low dose of DOJOLVI and slowly increase your dose to help avoid side effects.
- If you are taking another medium chain triglyceride (MCT) product, stop taking the MCT before starting DOJOLVI.
- Do not mix or give DOJOLVI using containers, dosing syringes or measuring cups made of polystyrene (a type of plastic that can be solid or foam) or polyvinyl chloride (PVC), a solid plastic material.
- DOJOLVI should be taken at least 4 times a day with meals or snacks, and always mixed well with soft food or drink.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in fallowing doasage form: As oral Liquidː 100% w/w of triheptanoin
This medicine is available in fallowing brand namesː
- DOJOLVI
What side effects can this medication cause?[edit | edit source]
Common possible side effects of this medicine include:
- abdominal pain
- diarrhea
- vomiting
- nausea
- Feeding tube problems
- Intestinal absorption problems in patients with pancreatic insufficiency
What special precautions should I follow?[edit | edit source]
- This medicine may cause feeding tube dysfunction regularly monitor the tube to ensure proper functioning and integrity.
- Low or absent pancreatic enzymes may reduce absorption of DOJOLVI. Avoid administration of DOJOLVI in patients with pancreatic insufficiency.
What to do in case of emergency/overdose?[edit | edit source]
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?[edit | edit source]
- There are no available data on triheptanoin use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
- Advise women to report pregnancies to Ultragenyx Pharmaceutical Inc. at 1-888-756-8657.
Can this medicine be used in children?[edit | edit source]
- The safety and effectiveness of DOJOLVI have been established in pediatric patients aged birth and older.
What should I know about storage and disposal of this medication?[edit | edit source]
- Store DOJOLVI at room temperature between 68°F to 77°F (20°C - 25°C).
- Do not freeze DOJOLVI.
- When the bottle of DOJOLVI has been opened, use within 9 months or by the expiration date on the bottle, whichever comes first.
- Do not store DOJOLVI in containers made of polystyrene or polyvinyl chloride (PVC).
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