Troponin I
Troponin I is a part of the troponin complex, a group of three regulatory proteins (troponin C, troponin T, and troponin I) that are integral to muscle contraction in skeletal and cardiac muscle. Troponin I is the inhibitory subunit of the troponin complex and it binds to actin in thin myofilaments to hold the tropomyosin molecule in place.
Structure[edit | edit source]
Troponin I is a 21-24 kDa protein that is composed of 190 amino acids. It has a single polypeptide chain and is divided into three distinct regions: the N-terminal region, the middle region, and the C-terminal region. The N-terminal region is highly conserved and is responsible for inhibiting the ATPase activity of actomyosin. The middle region binds to troponin C and the C-terminal region binds to troponin T and tropomyosin.
Function[edit | edit source]
The primary function of troponin I is to prevent muscle contraction in the absence of calcium ions. When calcium ions are present, they bind to troponin C, causing a conformational change in the troponin complex that allows for muscle contraction. Troponin I also plays a role in the regulation of cardiac muscle contraction and is a key player in the excitation-contraction coupling process.
Clinical significance[edit | edit source]
In clinical medicine, troponin I is often used as a diagnostic marker for myocardial infarction (heart attack). Levels of troponin I in the blood can rise within 3-4 hours of a heart attack and can remain elevated for up to 14 days. This makes it a valuable tool for diagnosing recent heart attacks. However, elevated levels of troponin I can also be seen in other conditions such as myocarditis, pulmonary embolism, and chronic kidney disease.
See also[edit | edit source]
- Troponin
- Troponin C
- Troponin T
- Myocardial infarction
- Myocarditis
- Pulmonary embolism
- Chronic kidney disease
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