Vesanoid

Vesanoid is a medication used in the treatment of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia. It is also known by its generic name, tretinoin, and is classified as a retinoid, which is a group of vitamin A derivatives.

Mechanism of Action

Vesanoid works by promoting the maturation of immature cells (promyelocytes) into mature blood cells in patients with APL. This process is known as cell differentiation. The drug binds to and activates retinoic acid receptors (RARs), which are involved in cell growth and differentiation.

Usage

Vesanoid is used primarily in the treatment of APL, particularly in cases where the disease has not responded to other forms of treatment. It is typically administered orally in capsule form. The dosage and duration of treatment are determined by the patient's body surface area and the severity of the disease.

Side Effects

Like all medications, Vesanoid can cause side effects. Common side effects include headache, fever, weakness, and fatigue. More serious side effects can include liver damage, high cholesterol, and an increased risk of infection due to a decrease in white blood cells.

Contraindications

Vesanoid is contraindicated in patients with a known hypersensitivity to tretinoin or any other ingredient in the formulation. It is also contraindicated in patients with pregnancy due to the risk of birth defects.

See Also

• Retinoid
• Acute promyelocytic leukemia
• Tretinoin

References

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