5-HT1F

5-HT1F receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and is expressed throughout the central nervous system (CNS).

Function

The 5-HT1F receptor is thought to play a role in the pathophysiology of migraine. Activation of this receptor has been shown to inhibit the release of calcitonin gene-related peptide (CGRP) from neurons in the trigeminal ganglion. CGRP is thought to play a key role in the pathogenesis of migraine. Therefore, 5-HT1F receptor agonists may be useful in the treatment of migraine.

Ligands

Several selective 5-HT1F receptor agonists are available for experimental use, including LY334370 and LY344864. These compounds have been shown to be effective in animal models of migraine. In addition, the non-selective 5-HT1F receptor agonist sumatriptan, which is used clinically for the treatment of migraine, has been shown to activate the 5-HT1F receptor.

Clinical significance

The 5-HT1F receptor is a potential target for the treatment of migraine. Several 5-HT1F receptor agonists are currently under development for this indication. These include lasmiditan, which is in phase III clinical trials, and LY334370, which has completed phase II clinical trials.

See also

• 5-HT receptor
• Serotonin
• Migraine
• G protein-coupled receptor

External links

• 5-HT1F at the IUPHAR Database

5-HT1F Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski