CXCR7

CXCR7 is a G protein-coupled receptor that in humans is encoded by the ACKR3 gene. It is also known as CXC chemokine receptor 7 and atypical chemokine receptor 3 (ACKR3). CXCR7 is a member of the chemokine receptor family, and was previously considered an orphan receptor because the chemokine ligand to which it binds was unknown.

Function

CXCR7 functions as a scavenger receptor for the chemokine SDF-1 (CXCL12), a molecule that has been implicated in the migration and homing of cancer cells, stem cells, and immune cells. It also binds to Interleukin 8 (CXCL8), but does not appear to transduce signals in response to this chemokine. Instead, it internalizes and degrades the chemokine.

Clinical significance

CXCR7 has been implicated in a number of diseases, including cancer, HIV, and atherosclerosis. In cancer, it is thought to play a role in tumor growth and metastasis. In HIV, it may function as a co-receptor for the virus. In atherosclerosis, it may play a role in the recruitment of inflammatory cells to the site of injury.

See also

• Chemokine receptor
• G protein-coupled receptor
• SDF-1
• Interleukin 8

References

CXCR7 Resources
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