Echothiophate iodide

Echothiophate Iodide is a pharmacological agent primarily used in the treatment of glaucoma and strabismus. It belongs to the class of organophosphates, which are potent inhibitors of cholinesterase.

Pharmacology[edit | edit source]

Echothiophate iodide works by inhibiting the enzyme acetylcholinesterase, which is responsible for the breakdown of acetylcholine in the body. By inhibiting this enzyme, echothiophate iodide increases the concentration of acetylcholine in the body, leading to increased stimulation of muscarinic receptors and nicotinic receptors. This increased stimulation results in the contraction of the ciliary muscle and the sphincter muscle of the iris, which in turn reduces intraocular pressure and helps in the treatment of glaucoma.

Clinical Use[edit | edit source]

Echothiophate iodide is used in the treatment of chronic glaucoma and strabismus. It is also used in diagnostic procedures to test for myasthenia gravis, a neuromuscular disease that causes weakness in the skeletal muscles.

Side Effects[edit | edit source]

The most common side effects of echothiophate iodide include blurred vision, eye pain, and increased tearing. Systemic side effects can occur if the drug is absorbed into the body and may include bradycardia, hypotension, and bronchospasm.

Contraindications[edit | edit source]

Echothiophate iodide is contraindicated in patients with known hypersensitivity to organophosphates. It should also be used with caution in patients with asthma, cardiac disease, or peptic ulcer disease due to the potential for systemic side effects.