Frameshift mutations
Frameshift mutations are a type of genetic mutation that involves the insertion or deletion of a nucleotide in the DNA sequence. This type of mutation can have significant effects on the protein produced by the gene in which the mutation occurs.
Overview[edit | edit source]
A frameshift mutation occurs when the number of nucleotides inserted or deleted is not a multiple of three. Because a set of three nucleotides, known as a codon, codes for a single amino acid, the insertion or deletion can disrupt the reading frame, or the grouping of the codons. This can result in a completely different translation from the original, or it can cause premature termination of protein synthesis.
Causes[edit | edit source]
Frameshift mutations can be caused by a variety of factors, including DNA replication errors, exposure to certain chemicals or radiation, and certain viral infections. They can also occur as a result of DNA repair mechanisms failing to correct these errors.
Effects[edit | edit source]
The effects of frameshift mutations can vary greatly depending on the specific mutation and where it occurs in the DNA sequence. In some cases, the mutation can result in a nonfunctional protein, while in others it can produce a protein with a completely different function. In some cases, frameshift mutations can lead to diseases such as cancer or genetic disorders.
See also[edit | edit source]
References[edit | edit source]
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