Galant

Galantamine is a alkaloid that is used in the treatment of Alzheimer's disease and other memory impairments. It is derived from the bulbs and flowers of the Galanthus (snowdrop), Narcissus (daffodil), and other plants. Galantamine is a cholinesterase inhibitor that works by increasing the amount of a certain substance in the brain that is needed for memory and thought.

History

Galantamine was first isolated from the bulbs of the Galanthus plant in the early 1950s. It was initially used in anesthesia to reverse the effects of muscle relaxants. In the 1990s, it was found to be effective in the treatment of Alzheimer's disease and was approved for this use in Europe and the United States.

Medical uses

Galantamine is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. It is believed to work by increasing the levels of acetylcholine in the brain, a neurotransmitter that is involved in memory and learning. Galantamine does this by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine.

Side effects

Common side effects of galantamine include nausea, vomiting, diarrhea, weight loss, and loss of appetite. Less common side effects include dizziness, headache, and fatigue. In rare cases, galantamine can cause more serious side effects such as slow heart rate, fainting, and seizures.

Pharmacology

Galantamine is a reversible, competitive acetylcholinesterase inhibitor. It also modulates the activity of nicotinic receptors, which are involved in the release of acetylcholine. This dual mechanism of action is thought to give galantamine an advantage over other cholinesterase inhibitors.

See also

• Alzheimer's disease
• Cholinesterase inhibitor
• Acetylcholine

Galant Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.